Hypertransfusion Management

Also known as: hypertransfusion therapy.

What is hypertransfusion management?

Hypertransfusion management is a form of blood transfusion that’s aimed at reducing the risk of complications such as stroke in patients with sickle cell disease.

What happens during the procedure?

For patients with a history of a stroke, hypertransfusion management is a simple transfusion to raise the hemoglobin concentration to approximately 10 g/dL. It reduces complications of sickle cell by using intermittent, long-term transfusions to dilute the blood. As with most blood transfusions, the blood is injected into the body via IV.

Is any special preparation needed?

Hypertransfusion management is a special procedure that’s only right for certain patients. Testing may be required to determine if it’s the proper treatment. Blood testing is required to determine the patient’s blood type. This way, compatible blood can be used for the transfusion.

What are the risk factors?

Infection, bleeding, bruising, shortness of breath and chest or back pain are potential risks of hypertransfusion management.

Reviewed by: Athena C Pefkarou, MD

This page was last updated on: 9/16/2025 12:49:14 PM

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Sickle Cell Disease Sickle cell disease is a group of familial red blood cell disorders. Sickle cell disease causes the red blood cells to be oddly shaped, and have difficulty flowing through the blood vessels properly which causes them to break up easily resulting in anemia and damage to the organs.
Iron Chelation Therapy Iron chelation therapy is a treatment used to remove excess iron from the blood.
Chronic Transfusion Therapy/Hypertransfusion Therapy Chronic transfusion therapy is a form of blood transfusion that is repeated on a “chronic,” or regular, basis.
Blood Transfusions A blood transfusion is when blood is infused into the body to replace missing blood.