Undifferentiated Embryonal Sarcoma of the Liver

Also known as: UESL

What is undifferentiated embryonal sarcoma of the liver?

Undifferentiated embryonal sarcoma of the liver, or UESL for short, is a rare form of liver cancer that primarily affects children. It’s the third most common form of liver cancer in kids and tends to grow aggressively.

What causes UESL?

Like most cancers, the root cause of UESL is due to changes in a cell’s DNA. What specifically causes this change to occur isn’t clear.

What are the symptoms of UESL?

In many cases, UESL doesn’t cause any noticeable symptoms. When it does, these symptoms can include abdominal pain or swelling, fatigue, fever, diarrhea, constipation, vomiting, loss of appetite and weight loss.

How can UESL affect children?

Most cases of UESL occur in children between the ages of 5 and 10. Though the cancer is aggressive, it can be cured with proper diagnosis and treatment.

What are UESL treatments?

Surgery to remove the tumor and aggressive chemotherapy are the standard methods of treatment for UESL.

Reviewed by: Maggie Fader, MD

This page was last updated on: July 29, 2025 05:45 PM

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