Liposarcoma

Also known as: well-differentiated liposarcoma, myxoid liposarcoma, pleomorphic liposarcoma, dedifferentiated liposarcoma.

What is liposarcoma?

Liposarcoma is a cancer of fat cells. It can occur anywhere in the body, but is commonly found in the abdomen, thigh or shoulder area. There are four microscopic subtypes which vary not only in how fast they grow but also in other characteristics. The commonest type usually grows slowly and doesn't spread.

What causes liposarcoma?

The cause of liposarcoma is not always clear; some types seem to have a genetic basis.

What are the symptoms of liposarcoma?

Children with a liposarcoma usually don't have any symptoms until it is very advanced. Initially, a tumor or lump of fat under the skin which is typically painless, may be felt.

Liposarcomas in the abdomen can grow quite large before symptoms occur.

What are liposarcoma care options?

The typical treatment for liposarcoma is surgery to remove the tumor; radiation may be used before, during or after surgery to both kill the tumor as well as preventing it from coming back. Chemotherapy is rarely used but may be recommended where recurrences or spread of the tumor are likely.

Reviewed by: Jack Wolfsdorf, MD, FAAP

This page was last updated on: September 16, 2025 12:13 PM