Cyclic Neutropenia

Also known as: CN, cyclic neutropenia, periodic neutropenia, cyclic hematopoiesis.

What is cyclic neutropenia?

Neutrophils (or white blood cells) are one type of body cell that fights infection. Children with cyclic neutropenia (usually diagnosed in their first year of life) have a fairly non-serious disease (benign) where their white blood cell count becomes low for 3-5 days, every 14-35 days. During each of these times they are susceptible to bacterial and viral infections.

What causes cyclic neutropenia?

Cyclic neutropenia is an inherited genetic disorder where one copy of the abnormal gene passed down from a parent is enough to cause the disease (autosomal dominant pattern). New gene abnormality (mutations) with no family history also occur and can result in the disorder.

What are the symptoms of cyclic neutropenia?

Recurrent fevers, sore gums and throat, respiratory and skin infections, sinus problems, and ulcers in the mouth and colon.
 

What are cyclic neutropenia care options?

Appropriate antibiotics to treat bacterial infections. Other drugs to increase the production of neutrophils may be tried.

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Reviewed by: Jack Wolfsdorf, MD, FAAP

This page was last updated on: September 09, 2025 10:21 AM