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Bethlem Myopathy

Also known as: muscular dystrophy, collagen VI-related myopathy.

What is bethlem myopathy?

Bethlem myopathy is a form of muscular dystrophy that causes joint stiffness and muscle weakness that gradually becomes worse over time. It often affects the feet, hands and elbows.

What causes bethlem myopathy?

Bethlem myopathy is caused by genetic mutations. These are passed down from parents to their children.

What are the symptoms of bethlem myopathy?

The wrists, elbows, fingers and ankles are the body parts primarily affected by Bethlem myopathy. Joint stiffness and muscle weakness that gradually worsen over time are the primary symptoms. Skin abnormalities are also common.

What are bethlem myopathy care options?

Physical therapy, stretching, assistive devices and other forms of therapy can help people live with the symptoms of Bethlem myopathy.

Reviewed by: Trevor J Resnick, MD

This page was last updated on: 9/16/2025 12:35:22 PM

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Lower extremity spasticity (leg & foot spasticity) Spasticity of the lower extremity ranges from mild to very disabling. The affected muscles may be over-active and cause joint contractures (stiff joints).
Upper extremity spasticity (arm & hand spasticity) Upper extremity spasticity refers to increased muscle tone and hyperactive reflexes in the arm. It is usually due to a problem with motor nerves in the brain, and can be caused by cerebral palsy, stroke or traumatic brain injury.
Spasticity and Contractures Spasticity and contractures are conditions in which muscle imbalance across a joint leads to abnormal positioning and tightness. Spasticity refers to involuntary tightening or stiffening of muscles. The term contracture refers to abnormal positioning of a joint.
Physical Therapy (PT) Evaluation and Treatment Physical therapy is a form of therapy that helps people rehabilitate through exercises, stretching and orthopedics in order to regain the mobility and function of their bodies.